3w59: Difference between revisions
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{{STRUCTURE_3w59| PDB=3w59 | SCENE= }} | |||
===Crystal structure of Galectin-1 in the lactose-unbound state(P212121)=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | |||
==About this Structure== | |||
[[3w59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W59 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Kunishima, N.]] | |||
[[Category: Saburi, H.]] | |||
[[Category: Tanaka, T.]] | |||
[[Category: Galectin]] | |||
[[Category: Lactose unbound state]] | |||
[[Category: Lectin]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 07:42, 29 January 2014
Crystal structure of Galectin-1 in the lactose-unbound state(P212121)
Function
[LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.[1] [2]
About this Structure
3w59 is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ He J, Baum LG. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 6;279(6):4705-12. Epub 2003 Nov 14. PMID:14617626 doi:10.1074/jbc.M311183200
- ↑ Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008 Dec;18(12):1065-73. Epub 2008 Sep 16. PMID:18796645 doi:10.1093/glycob/cwn089
