3b8z: Difference between revisions
New page: left|200px<br /><applet load="3b8z" size="350" color="white" frame="true" align="right" spinBox="true" caption="3b8z, resolution 1.400Å" /> '''High Resolution Cry... |
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==Overview== | ==Overview== | ||
Aggrecanase-2 | Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2007 Nov 8 | High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Mathis, K | [[Category: Mathis, K J.]] | ||
[[Category: Shieh, H | [[Category: Shieh, H S.]] | ||
[[Category: Tomasselli, A.]] | [[Category: Tomasselli, A.]] | ||
[[Category: Tortorella, M | [[Category: Tortorella, M D.]] | ||
[[Category: Williams, J | [[Category: Williams, J M.]] | ||
[[Category: 294]] | [[Category: 294]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:18 2008'' | ||
Revision as of 17:04, 21 February 2008
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High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Overview
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
About this Structure
3B8Z is a Single protein structure of sequence from Homo sapiens with ZN, CA and 294 as ligands. Full crystallographic information is available from OCA.
Reference
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750
Page seeded by OCA on Thu Feb 21 19:04:18 2008
