3dqb: Difference between revisions
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{{STRUCTURE_3dqb| PDB=3dqb | SCENE= }} | {{STRUCTURE_3dqb| PDB=3dqb | SCENE= }} | ||
===Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin=== | ===Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin=== | ||
{{ABSTRACT_PUBMED_18818650}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018818650</ref><references group="xtra"/> | <ref group="xtra">PMID:018818650</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Choe, H W.]] | [[Category: Choe, H W.]] | ||
Revision as of 07:30, 5 February 2014
Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin
Template:ABSTRACT PUBMED 18818650
Function
[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
About this Structure
3dqb is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
See Also
Reference
- Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP. Crystal structure of opsin in its G-protein-interacting conformation. Nature. 2008 Sep 25;455(7212):497-502. PMID:18818650 doi:10.1038/nature07330
- ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
- ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Bos taurus
- Choe, H W.
- Ernst, O P.
- Hildebrand, P W.
- Hofmann, K P.
- Kim, Y J.
- Krauss, N.
- Park, J H.
- Scheerer, P.
- Chromophore
- G-protein
- G-protein coupled receptor
- G-protein-coupled receptor
- Galpha subunit
- Glycoprotein
- Gtp-binding
- Ligand-free state
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Opsin
- Palmitate
- Phosphoprotein
- Photoreceptor
- Photoreceptor protein
- Protein
- Receptor
- Retinal protein
- Rhodopsin
- Sensory transduction
- Signaling protein
- Transducer
- Transducin
- Transmembrane
- Vision
