2xfh: Difference between revisions

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{{STRUCTURE_2xfh|  PDB=2xfh  |  SCENE=  }}  
{{STRUCTURE_2xfh|  PDB=2xfh  |  SCENE=  }}  
===STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.===
===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.===
{{ABSTRACT_PUBMED_20845962}}
{{ABSTRACT_PUBMED_20845962}}
==Function==
[[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref> 


==About this Structure==
==About this Structure==
[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].  
[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>
[[Category: Saccharopolyspora erythraea]]
[[Category: Gianni, S.]]
[[Category: Gianni, S.]]
[[Category: Montemiglio, L C.]]
[[Category: Montemiglio, L C.]]

Revision as of 08:04, 5 February 2014

Template:STRUCTURE 2xfh

Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.

Template:ABSTRACT PUBMED 20845962

About this Structure

2xfh is a 1 chain structure with sequence from "actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923. This structure supersedes the now removed PDB entry 2vrv. Full crystallographic information is available from OCA.

Reference

  1. Montemiglio LC, Gianni S, Vallone B, Savino C. Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry. 2010 Sep 16. PMID:20845962 doi:10.1021/bi101062v

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