4l01: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4l01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4l01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L01 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024013208</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024013208</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Eck, M J.]] | [[Category: Eck, M J.]] | ||
Revision as of 09:05, 5 February 2014
Crystal structure of the V658F apo Jak1 pseudokinase domain
Template:ABSTRACT PUBMED 24013208
Function
[JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
About this Structure
4l01 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Sep 8. doi: 10.1038/nsmb.2673. PMID:24013208 doi:10.1038/nsmb.2673
