4j1l: Difference between revisions
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{{STRUCTURE_4j1l| PDB=4j1l | SCENE= }} | |||
===Mutant Endotoxin TeNT=== | |||
{{ABSTRACT_PUBMED_23994593}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE]] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
==About this Structure== | |||
[[4j1l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1L OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023994593</ref><references group="xtra"/><references/> | |||
[[Category: Tentoxilysin]] | |||
[[Category: Chen, S.]] | |||
[[Category: Guo, J.]] | |||
[[Category: Pan, X.]] | |||
[[Category: Zhao, Y.]] | |||
[[Category: Endotoxin]] | |||
[[Category: Toxin]] | |||
Revision as of 11:02, 5 February 2014
Mutant Endotoxin TeNT
Template:ABSTRACT PUBMED 23994593
Function
[TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
About this Structure
4j1l is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Guo J, Pan X, Zhao Y, Chen S. Engineering Clostridia Neurotoxins with elevated catalytic activity. Toxicon. 2013 Nov;74:158-66. doi: 10.1016/j.toxicon.2013.08.055. Epub 2013 Aug, 29. PMID:23994593 doi:https://dx.doi.org/10.1016/j.toxicon.2013.08.055
