4nuu: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)===

~~The entry 4nuu~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

~~Authors~~: ~~Tolia, N~~.H.

==About this Structure==

[[4nuu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA].

~~Description~~: ~~Heterotrimer structure of Region II from Plasmodium vivax~~ Duffy ~~Binding~~ Protein ~~(PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)~~

==Reference==

[[Category: Tolia, N H.]]

[[Category: Adhesion]]

[[Category: Cell invasion]]

[[Category: Chemokine binding]]

[[Category: Duffy antigen receptor for chemokine]]

[[Category: Gpcr]]

[[Category: Invasion]]

[[Category: Membrane]]

[[Category: Membrane protein]]

[[Category: Protein binding]]

[[Category: Red blood cell binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nuu|  PDB=4nuu  |  SCENE=  }}
+===Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)===
+{{ABSTRACT_PUBMED_24415938}}
-The entry 4nuu is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
-Authors: Tolia, N.H.
+==About this Structure==
+[[4nuu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA].
-Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
+==Reference==
+<ref group="xtra">PMID:024415938</ref><references group="xtra"/><references/>
+[[Category: Tolia, N H.]]
+[[Category: Adhesion]]
+[[Category: Cell invasion]]
+[[Category: Chemokine binding]]
+[[Category: Duffy antigen receptor for chemokine]]
+[[Category: Gpcr]]
+[[Category: Invasion]]
+[[Category: Membrane]]
+[[Category: Membrane protein]]
+[[Category: Protein binding]]
+[[Category: Red blood cell binding]]