4mr0: Difference between revisions
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{{STRUCTURE_4mr0| PDB=4mr0 | SCENE= }} | |||
===Crystal structure of PfbA, a surface adhesin of Streptococcus pneumoniae=== | |||
{{ABSTRACT_PUBMED_24321492}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PFBA_STRR6 PFBA_STRR6]] Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood. | |||
==About this Structure== | |||
[[4mr0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR0 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024321492</ref><references group="xtra"/><references/> | |||
[[Category: Beulin, D S.J.]] | |||
[[Category: Ponnuraj, K.]] | |||
[[Category: Adhesion]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Fibronectin]] | |||
[[Category: Plasimin and fibronectin-binding protein]] | |||
[[Category: Plasminogen]] | |||
[[Category: Surface protein]] | |||