2mh3: Difference between revisions
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{{STRUCTURE_2mh3| PDB=2mh3 | SCENE= }} | |||
===NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1=== | |||
{{ABSTRACT_PUBMED_24403087}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref> | |||
==About this Structure== | |||
[[2mh3]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024403087</ref><references group="xtra"/><references/> | |||
[[Category: Boelens, R.]] | |||
[[Category: Coglievina, M.]] | |||
[[Category: Pintar, A.]] | |||
[[Category: Pongor, S.]] | |||
[[Category: Popovic, M.]] | |||
[[Category: Wienk, H.]] | |||
[[Category: Bhlh]] | |||
[[Category: Dna binding protein]] | |||
Revision as of 11:11, 5 February 2014
NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1
Template:ABSTRACT PUBMED 24403087
Function
[HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.[1]
About this Structure
2mh3 is a 2 chain structure. Full experimental information is available from OCA.
Reference
- Popovic M, Wienk H, Coglievina M, Boelens R, Pongor S, Pintar A. The basic-helix-loop-helix region of the transcriptional repressor HES-1 is preorganized to bind DNA. Proteins. 2014 Jan 8. doi: 10.1002/prot.24507. PMID:24403087 doi:https://dx.doi.org/10.1002/prot.24507
- ↑ Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Levesque G, Carreau M. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008 Sep 1;112(5):2062-70. doi: 10.1182/blood-2008-04-152710. Epub 2008, Jun 11. PMID:18550849 doi:https://dx.doi.org/10.1182/blood-2008-04-152710
