4nuv: Difference between revisions
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{{STRUCTURE_4nuv| PDB=4nuv | SCENE= }} | |||
===Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)=== | |||
{{ABSTRACT_PUBMED_24415938}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. | |||
==About this Structure== | |||
[[4nuv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUV OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024415938</ref><references group="xtra"/><references/> | |||
[[Category: Tolia, N H.]] | |||
[[Category: Adhesion]] | |||
[[Category: Cell invasion]] | |||
[[Category: Chemokine binding]] | |||
[[Category: Duffy antigen receptor for chemokine]] | |||
[[Category: Gpcr]] | |||
[[Category: Invasion]] | |||
[[Category: Membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Protein binding]] | |||
[[Category: Red blood cell binding]] | |||
Revision as of 11:16, 5 February 2014
Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
Template:ABSTRACT PUBMED 24415938
Function
[PVDR_PLAVS] Binds to the human erythrocytes Duffy blood group determinant. [ACKR1_HUMAN] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
About this Structure
4nuv is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Batchelor JD, Malpede BM, Omattage NS, Dekoster GT, Henzler-Wildman KA, Tolia NH. Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC. PLoS Pathog. 2014 Jan;10(1):e1003869. doi: 10.1371/journal.ppat.1003869. Epub, 2014 Jan 9. PMID:24415938 doi:https://dx.doi.org/10.1371/journal.ppat.1003869
