4gfx: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the N-terminal domain of TXNIP===

~~The entry 4gfx is ON HOLD~~ ~~until Feb 05 2015~~

==Function==

[[http://www.uniprot.org/uniprot/TXNIP_HUMAN TXNIP_HUMAN]] May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).<ref>PMID:17603038</ref> <ref>PMID:12821938</ref> <ref>PMID:18541147</ref> <ref>PMID:21460850</ref>

~~Authors~~: ~~Hwang, J~~.~~, Kim, M~~.H.

==About this Structure==

[[4gfx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFX OCA].

~~Description~~: ~~Crystal structure of the N~~-~~terminal domain of TXNIP~~

==Reference==

[[Category: Hwang, J.]]

[[Category: Kim, M H.]]

[[Category: Arrestin-like fold]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gfx|  PDB=4gfx  |  SCENE=  }}
+===Crystal structure of the N-terminal domain of TXNIP===
+{{ABSTRACT_PUBMED_24389582}}
-The entry 4gfx is ON HOLD  until Feb 05 2015
+==Function==
+[[http://www.uniprot.org/uniprot/TXNIP_HUMAN TXNIP_HUMAN]] May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).<ref>PMID:17603038</ref> <ref>PMID:12821938</ref> <ref>PMID:18541147</ref> <ref>PMID:21460850</ref>
-Authors: Hwang, J., Kim, M.H.
+==About this Structure==
+[[4gfx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFX OCA].
-Description: Crystal structure of the N-terminal domain of TXNIP
+==Reference==
+<ref group="xtra">PMID:024389582</ref><references group="xtra"/><references/>
+[[Category: Hwang, J.]]
+[[Category: Kim, M H.]]
+[[Category: Arrestin-like fold]]
+[[Category: Protein binding]]