4n8v: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-A===

The ~~entry 4n8v~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

~~Authors~~: ~~Liu, J~~.X., ~~Ren~~, E.C.

==Function==

[[http://www.uniprot.org/uniprot/A14_VACCW A14_VACCW]] Envelope protein which is a major component of the mature virion (MV) membrane. Essential for membrane biogenesis. Is required, together with A17, to form bona fide crescents, which can progress to form the immature virion (IV) membrane. A14 and A17 form a lattice that is stabilized by disulfide bonds and serves as an anchor within the viral membrane to which several other proteins important in virion structure and morphogenesis attach.<ref>PMID:9445029</ref> <ref>PMID:10729144</ref> [[http://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN]] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/1A11_HUMAN 1A11_HUMAN]] Involved in the presentation of foreign antigens to the immune system.

~~Description~~: ~~Crystal structure of killer cell immunoglobulin~~-~~like receptor KIR2DS2 in complex with HLA-A~~

==About this Structure==

[[4n8v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8V OCA].

==Reference==

[[Category: Liu, J X.]]

[[Category: Ren, E C.]]

[[Category: Activating kir]]

[[Category: Antigen presentation]]

[[Category: Cell lysing]]

[[Category: Immune system]]

[[Category: Kir binding]]

[[Category: Kir2ds2]]

[[Category: Membrane]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4n8v|  PDB=4n8v  |  SCENE=  }}
+===Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-A===
-The entry 4n8v is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-Authors: Liu, J.X., Ren, E.C.
+==Function==
+[[http://www.uniprot.org/uniprot/A14_VACCW A14_VACCW]] Envelope protein which is a major component of the mature virion (MV) membrane. Essential for membrane biogenesis. Is required, together with A17, to form bona fide crescents, which can progress to form the immature virion (IV) membrane. A14 and A17 form a lattice that is stabilized by disulfide bonds and serves as an anchor within the viral membrane to which several other proteins important in virion structure and morphogenesis attach.<ref>PMID:9445029</ref> <ref>PMID:10729144</ref>  [[http://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN]] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/1A11_HUMAN 1A11_HUMAN]] Involved in the presentation of foreign antigens to the immune system.
-Description: Crystal structure of killer cell immunoglobulin-like receptor KIR2DS2 in complex with HLA-A
+==About this Structure==
+[[4n8v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8V OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Liu, J X.]]
+[[Category: Ren, E C.]]
+[[Category: Activating kir]]
+[[Category: Antigen presentation]]
+[[Category: Cell lysing]]
+[[Category: Immune system]]
+[[Category: Kir binding]]
+[[Category: Kir2ds2]]
+[[Category: Membrane]]