4o6a: Difference between revisions
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{{STRUCTURE_4o6a| PDB=4o6a | SCENE= }} | |||
===Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | |||
==About this Structure== | |||
[[4o6a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6A OCA]. | |||
[[Category: Cyclic GMP-AMP synthase]] | |||
[[Category: Chen, Z.]] | |||
[[Category: Chen, Z J.]] | |||
[[Category: Zhang, X.]] | |||
[[Category: Zhang, X W.]] | |||
[[Category: Immune response]] | |||
[[Category: Transferase-dna complex]] | |||
Revision as of 11:38, 5 February 2014
Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4o6a is a 6 chain structure. Full crystallographic information is available from OCA.
