3i4w: Difference between revisions
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===Crystal Structure of the third PDZ domain of PSD-95=== | ===Crystal Structure of the third PDZ domain of PSD-95=== | ||
{{ABSTRACT_PUBMED_20227506}} | {{ABSTRACT_PUBMED_20227506}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020227506</ref><references group="xtra"/> | <ref group="xtra">PMID:020227506</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Camara-Artigas, A.]] | [[Category: Camara-Artigas, A.]] | ||
[[Category: Gavira, J A.]] | [[Category: Gavira, J A.]] | ||
