3d12: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
===Crystal Structures of Nipah Virus G Attachment Glycoprotein in Complex with its Receptor Ephrin-B3=== | ===Crystal Structures of Nipah Virus G Attachment Glycoprotein in Complex with its Receptor Ephrin-B3=== | ||
{{ABSTRACT_PUBMED_18632560}} | {{ABSTRACT_PUBMED_18632560}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLYCP_NIPAV GLYCP_NIPAV]] Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:17470910</ref> <ref>PMID:15961384</ref> [[http://www.uniprot.org/uniprot/EFNB3_MOUSE EFNB3_MOUSE]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:10704386</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3d12]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3d12]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Nipav Nipav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D12 OCA]. | ||
==See Also== | ==See Also== | ||
| Line 10: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018632560</ref><references group="xtra"/> | <ref group="xtra">PMID:018632560</ref><references group="xtra"/><references/> | ||
[[Category: Exo-alpha-sialidase]] | [[Category: Exo-alpha-sialidase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: | [[Category: Nipav]] | ||
[[Category: Broder, C C.]] | [[Category: Broder, C C.]] | ||
[[Category: Chan, Y P.]] | [[Category: Chan, Y P.]] | ||
