3loj: Difference between revisions
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{{STRUCTURE_3loj| PDB=3loj | SCENE= }} | {{STRUCTURE_3loj| PDB=3loj | SCENE= }} | ||
===Structure of Mycobacterium tuberculosis dUTPase H145A mutant=== | ===Structure of Mycobacterium tuberculosis dUTPase H145A mutant=== | ||
{{ABSTRACT_PUBMED_20601405}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | |||
==About this Structure== | ==About this Structure== | ||
[[3loj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3loj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOJ OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020601405</ref><references group="xtra"/> | <ref group="xtra">PMID:020601405</ref><references group="xtra"/><references/> | ||
[[Category: DUTP diphosphatase]] | [[Category: DUTP diphosphatase]] | ||
[[Category: Harmat, V.]] | [[Category: Harmat, V.]] | ||
Revision as of 04:31, 13 February 2014
Structure of Mycobacterium tuberculosis dUTPase H145A mutant
Template:ABSTRACT PUBMED 20601405
Function
[DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
About this Structure
3loj is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.
See Also
Reference
- Pecsi I, Leveles I, Harmat V, Vertessy BG, Toth J. Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res. 2010 Jul 2. PMID:20601405 doi:10.1093/nar/gkq584
