3whw: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_3whw|  PDB=3whw  |  SCENE=  }}
===MTH1 in complex with Ruthenium-based inhibitor===
{{ABSTRACT_PUBMED_24258965}}


The entry 3whw is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>  


Authors: Streib, M., Kraeling, K., Richter, K., Steuber, H., Meggers, E.
==About this Structure==
[[3whw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA].  


Description: MTH1 in complex with Ruthenium-based inhibitor
==Reference==
<ref group="xtra">PMID:024258965</ref><references group="xtra"/><references/>
[[Category: Kraeling, K.]]
[[Category: Meggers, E.]]
[[Category: Richter, K.]]
[[Category: Steuber, H.]]
[[Category: Streib, M.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Mth1]]
[[Category: Organometallic inhibitor]]
Retrieved from "https://proteopedia.org/3whw"