4kyp: Difference between revisions
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{{STRUCTURE_4kyp| PDB=4kyp | SCENE= }} | |||
===Beta-Scorpion Toxin folded in the periplasm of E.coli=== | |||
{{ABSTRACT_PUBMED_23999087}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SIXE_HOTJU SIXE_HOTJU]] Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects. | |||
==About this Structure== | |||
[[4kyp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYP OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023999087</ref><references group="xtra"/><references/> | |||
[[Category: Cole, A R.]] | |||
[[Category: Lampert, A.]] | |||
[[Category: Lopes, J L.]] | |||
[[Category: Reilly, A OO.]] | |||
[[Category: Wallace, B A.]] | |||
[[Category: Alpha-beta]] | |||
[[Category: Toxin]] | |||
[[Category: Venom]] | |||
[[Category: Voltage gated na-channel]] | |||
Revision as of 05:06, 13 February 2014
Beta-Scorpion Toxin folded in the periplasm of E.coli
Template:ABSTRACT PUBMED 23999087
Function
[SIXE_HOTJU] Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.
About this Structure
4kyp is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- O'Reilly AO, Cole AR, Lopes JL, Lampert A, Wallace BA. Chaperone-mediated native folding of a beta-scorpion toxin in the periplasm of Escherichia coli. Biochim Biophys Acta. 2014 Jan;1840(1):10-5. doi: 10.1016/j.bbagen.2013.08.021., Epub 2013 Aug 30. PMID:23999087 doi:https://dx.doi.org/10.1016/j.bbagen.2013.08.021
