4bjo: Difference between revisions
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{{STRUCTURE_4bjo| PDB=4bjo | SCENE= }} | |||
===Nitrate in the active site of PTP1b is a putative mimetic of the transition state=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
==About this Structure== | |||
[[4bjo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJO OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Kenny, P W.]] | |||
[[Category: Newman, J.]] | |||
[[Category: Peat, T S.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase]] | |||
[[Category: Quantum chemistry]] | |||
[[Category: Transition state]] | |||
Revision as of 05:14, 13 February 2014
Nitrate in the active site of PTP1b is a putative mimetic of the transition state
Function
[PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]
About this Structure
4bjo is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
- ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329
