4nok: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain at pH 7.5===

~~The entry 4nok is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/LGMN_MOUSE LGMN_MOUSE]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.<ref>PMID:9742219</ref> <ref>PMID:17350006</ref> <ref>PMID:21292981</ref>

~~Authors~~: ~~Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L~~.~~, Ouyang, S~~.~~, Liu, Z~~.J.

==About this Structure==

[[4nok]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOK OCA].

~~Description~~:

==Reference==

[[Category: Legumain]]

[[Category: Ding, W.]]

[[Category: Hua, T.]]

[[Category: Jiao, L.]]

[[Category: Liu, Z J.]]

[[Category: Ni, X.]]

[[Category: Ouyang, S.]]

[[Category: Qu, L.]]

[[Category: Ru, H.]]

[[Category: Shaw, N.]]

[[Category: Zhao, L.]]

[[Category: Asparaginyl endopeptidase]]

[[Category: Extracellular]]

[[Category: Hydrolase]]

[[Category: New fold]]

[[Category: Substrate]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nok|  PDB=4nok  |  SCENE=  }}
+===Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain at pH 7.5===
+{{ABSTRACT_PUBMED_24407422}}
-The entry 4nok is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/LGMN_MOUSE LGMN_MOUSE]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.<ref>PMID:9742219</ref> <ref>PMID:17350006</ref> <ref>PMID:21292981</ref>
-Authors: Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
+==About this Structure==
+[[4nok]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOK OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:024407422</ref><references group="xtra"/><references/>
+[[Category: Legumain]]
+[[Category: Ding, W.]]
+[[Category: Hua, T.]]
+[[Category: Jiao, L.]]
+[[Category: Liu, Z J.]]
+[[Category: Ni, X.]]
+[[Category: Ouyang, S.]]
+[[Category: Qu, L.]]
+[[Category: Ru, H.]]
+[[Category: Shaw, N.]]
+[[Category: Zhao, L.]]
+[[Category: Asparaginyl endopeptidase]]
+[[Category: Extracellular]]
+[[Category: Hydrolase]]
+[[Category: New fold]]
+[[Category: Substrate]]