4n9e: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===

~~The entry 4n9e~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

~~Authors~~: ~~Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y, Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y~~.~~, Yuen, P~~.~~, Zak, M~~.~~, Zheng, X~~.

==About this Structure==

[[4n9e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9E OCA].

~~Description~~: ~~Fragment-based Design of 3~~-~~Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)~~

==Reference==

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Baumeister, T.]]

[[Category: Bravo, B.]]

[[Category: Brien, T O.]]

[[Category: Dragovich, P S.]]

[[Category: Giannetti, A M.]]

[[Category: Ho, Y.]]

[[Category: Hua, R.]]

[[Category: Li, G.]]

[[Category: Liang, X.]]

[[Category: Oh, A.]]

[[Category: Skelton, N J.]]

[[Category: Wang, C.]]

[[Category: Wang, W.]]

[[Category: Wang, Y.]]

[[Category: Xiao, Y.]]

[[Category: Yuen, P.]]

[[Category: Zak, M.]]

[[Category: Zhao, G.]]

[[Category: Zhao, Q.]]

[[Category: Zheng, X.]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4n9e|  PDB=4n9e  |  SCENE=  }}
+===Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
+{{ABSTRACT_PUBMED_24433859}}
-The entry 4n9e is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y, Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
+==About this Structure==
+[[4n9e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9E OCA].
-Description: Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
+==Reference==
+<ref group="xtra">PMID:024433859</ref><references group="xtra"/><references/>
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Baumeister, T.]]
+[[Category: Bravo, B.]]
+[[Category: Brien, T O.]]
+[[Category: Dragovich, P S.]]
+[[Category: Giannetti, A M.]]
+[[Category: Ho, Y.]]
+[[Category: Hua, R.]]
+[[Category: Li, G.]]
+[[Category: Liang, X.]]
+[[Category: Oh, A.]]
+[[Category: Skelton, N J.]]
+[[Category: Wang, C.]]
+[[Category: Wang, W.]]
+[[Category: Wang, Y.]]
+[[Category: Xiao, Y.]]
+[[Category: Yuen, P.]]
+[[Category: Zak, M.]]
+[[Category: Zhao, G.]]
+[[Category: Zhao, Q.]]
+[[Category: Zheng, X.]]
+[[Category: Transferase-transferase inhibitor complex]]