4oih: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Importin Alpha in Complex with the Bipartite NLS of Prp20===

The ~~entry 4oih~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/RCC1_YEAST RCC1_YEAST]] Guanine nucleotide exchange factor that promotes the exchange of GSP1/GSP2-bound GDP by GTP and controls RNA metabolism and transport. Involved in yeast pheromone response pathway and in mRNA metabolism. Involved in nuclear pore complex (NPC) assembly and required for mRNA and ribosome nuclear export. Binds chromatin and is involved NPC-mediated transcriptional control.<ref>PMID:2548085</ref> <ref>PMID:2277633</ref> <ref>PMID:1666302</ref> <ref>PMID:1865879</ref> <ref>PMID:1398069</ref> <ref>PMID:7679070</ref> <ref>PMID:8070652</ref> <ref>PMID:9971735</ref> <ref>PMID:11071906</ref> <ref>PMID:11142374</ref> <ref>PMID:11509570</ref> <ref>PMID:11589573</ref> <ref>PMID:12654904</ref> <ref>PMID:16365162</ref>

~~Authors~~: ~~Roman, N., Christie, M., Swarbrick, C.M.D~~.~~, Kobe, B~~.~~, Forwood, J~~.K.

==About this Structure==

[[4oih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIH OCA].

~~Description~~: ~~Importin Alpha in Complex with the~~ Bipartite ~~NLS of~~ Prp20

==Reference==

[[Category: Christie, M.]]

[[Category: Forwood, J K.]]

[[Category: Kobe, B.]]

[[Category: Roman, N.]]

[[Category: Swarbrick, C M.D.]]

[[Category: Bipartite nl]]

[[Category: Nuclear localisation]]

[[Category: Protein transport-nuclear protein complex]]

[[Category: Prp20]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4oih|  PDB=4oih  |  SCENE=  }}
+===Importin Alpha in Complex with the Bipartite NLS of Prp20===
+{{ABSTRACT_PUBMED_24339986}}
-The entry 4oih is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/RCC1_YEAST RCC1_YEAST]] Guanine nucleotide exchange factor that promotes the exchange of GSP1/GSP2-bound GDP by GTP and controls RNA metabolism and transport. Involved in yeast pheromone response pathway and in mRNA metabolism. Involved in nuclear pore complex (NPC) assembly and required for mRNA and ribosome nuclear export. Binds chromatin and is involved NPC-mediated transcriptional control.<ref>PMID:2548085</ref> <ref>PMID:2277633</ref> <ref>PMID:1666302</ref> <ref>PMID:1865879</ref> <ref>PMID:1398069</ref> <ref>PMID:7679070</ref> <ref>PMID:8070652</ref> <ref>PMID:9971735</ref> <ref>PMID:11071906</ref> <ref>PMID:11142374</ref> <ref>PMID:11509570</ref> <ref>PMID:11589573</ref> <ref>PMID:12654904</ref> <ref>PMID:16365162</ref>
-Authors: Roman, N., Christie, M., Swarbrick, C.M.D., Kobe, B., Forwood, J.K.
+==About this Structure==
+[[4oih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIH OCA].
-Description: Importin Alpha in Complex with the Bipartite NLS of Prp20
+==Reference==
+<ref group="xtra">PMID:024339986</ref><references group="xtra"/><references/>
+[[Category: Christie, M.]]
+[[Category: Forwood, J K.]]
+[[Category: Kobe, B.]]
+[[Category: Roman, N.]]
+[[Category: Swarbrick, C M.D.]]
+[[Category: Bipartite nl]]
+[[Category: Nuclear localisation]]
+[[Category: Protein transport-nuclear protein complex]]
+[[Category: Prp20]]