4n7g: Difference between revisions
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{{STRUCTURE_4n7g| PDB=4n7g | SCENE= }} | |||
===Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS=== | |||
{{ABSTRACT_PUBMED_24504455}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> | |||
==About this Structure== | |||
[[4n7g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7G OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024504455</ref><references group="xtra"/><references/> | |||
[[Category: Bier, D.]] | |||
[[Category: Glas, A.]] | |||
[[Category: Grossmann, T.]] | |||
[[Category: Hahne, G.]] | |||
[[Category: Ottmann, C.]] | |||
[[Category: 14-3-3]] | |||
[[Category: Adaptor protein]] | |||
[[Category: Cross-link]] | |||
[[Category: Protein-protein interaction]] | |||
[[Category: Signaling protein]] | |||
Revision as of 17:30, 19 February 2014
Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS
Template:ABSTRACT PUBMED 24504455
Function
[1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.[1] [2] [3] [4] [5]
About this Structure
4n7g is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Glas A, Bier D, Hahne G, Rademacher C, Ottmann C, Grossmann TN. Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction. Angew Chem Int Ed Engl. 2014 Feb 6. doi: 10.1002/anie.201310082. PMID:24504455 doi:https://dx.doi.org/10.1002/anie.201310082
- ↑ Dubois T, Rommel C, Howell S, Steinhussen U, Soneji Y, Morrice N, Moelling K, Aitken A. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. J Biol Chem. 1997 Nov 14;272(46):28882-8. PMID:9360956
- ↑ Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nat Struct Biol. 2003 Dec;10(12):1054-7. Epub 2003 Oct 26. PMID:14578935 doi:10.1038/nsb1005
- ↑ Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004 Apr 21;23(8):1889-99. Epub 2004 Apr 8. PMID:15071501 doi:10.1038/sj.emboj.7600194
- ↑ Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7. Epub 2005 Jan 11. PMID:15644438 doi:0406871102
- ↑ Gu YM, Jin YH, Choi JK, Baek KH, Yeo CY, Lee KY. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. FEBS Lett. 2006 Jan 9;580(1):305-10. Epub 2005 Dec 19. PMID:16376338 doi:S0014-5793(05)01485-7
