4niy: Difference between revisions
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{{STRUCTURE_4niy| PDB=4niy | SCENE= }} | |||
===Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)=== | |||
{{ABSTRACT_PUBMED_24520050}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/ECOT_ECOLI ECOT_ECOLI]] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706] | |||
==About this Structure== | |||
[[4niy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIY OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024520050</ref><references group="xtra"/><references/> | |||
[[Category: Trypsin]] | |||
[[Category: Parthier, C.]] | |||
[[Category: Schoepfel, M.]] | |||
[[Category: Stubbs, M T.]] | |||
[[Category: Activation domain]] | |||
[[Category: Enzyme design]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Peptide ligation]] | |||
[[Category: Reverse proteolysis]] | |||
[[Category: Serine proteinase]] | |||
[[Category: Trypsin inhibitor]] | |||
Revision as of 17:36, 19 February 2014
Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)
Template:ABSTRACT PUBMED 24520050
Function
[ECOT_ECOLI] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]
About this Structure
4niy is a 8 chain structure. Full crystallographic information is available from OCA.
Reference
- Liebscher S, Schopfel M, Aumuller T, Sharkhuukhen A, Pech A, Hoss E, Parthier C, Jahreis G, Stubbs MT, Bordusa F. N-Terminal Protein Modification by Substrate-Activated Reverse Proteolysis. Angew Chem Int Ed Engl. 2014 Feb 12. doi: 10.1002/anie.201307736. PMID:24520050 doi:https://dx.doi.org/10.1002/anie.201307736
