4oe5: Difference between revisions
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{{STRUCTURE_4oe5| PDB=4oe5 | SCENE= }} | |||
===Structure of Human ALDH4A1 Crystallized in Space Group P21=== | |||
{{ABSTRACT_PUBMED_24502590}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN]] Hyperprolinemia type 2. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AL4A1_HUMAN AL4A1_HUMAN]] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.<ref>PMID:22516612</ref> | |||
==About this Structure== | |||
[[4oe5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OE5 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024502590</ref><references group="xtra"/><references/> | |||
[[Category: L-glutamate gamma-semialdehyde dehydrogenase]] | |||
[[Category: Tanner, J J.]] | |||
[[Category: Aldehyde dehydrogenase]] | |||
[[Category: Aldh4a1]] | |||
[[Category: Mitochondria]] | |||
[[Category: Nad]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Rossmann fold]] | |||
Revision as of 17:38, 19 February 2014
Structure of Human ALDH4A1 Crystallized in Space Group P21
Template:ABSTRACT PUBMED 24502590
Disease
[AL4A1_HUMAN] Hyperprolinemia type 2. The disease is caused by mutations affecting the gene represented in this entry.
Function
[AL4A1_HUMAN] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.[1]
About this Structure
4oe5 is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Pemberton TA, Srivastava D, Sanyal N, Henzl MT, Becker DF, Tanner JJ. Structural Studies of Yeast Delta-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State. Biochemistry. 2014 Feb 17. PMID:24502590 doi:https://dx.doi.org/10.1021/bi500048b
- ↑ Srivastava D, Singh RK, Moxley MA, Henzl MT, Becker DF, Tanner JJ. The Three-Dimensional Structural Basis of Type II Hyperprolinemia. J Mol Biol. 2012 Apr 16. PMID:22516612 doi:10.1016/j.jmb.2012.04.010
