4m6b: Difference between revisions
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{{STRUCTURE_4m6b| PDB=4m6b | SCENE= }} | |||
===Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer=== | |||
{{ABSTRACT_PUBMED_24507717}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref> [[http://www.uniprot.org/uniprot/SWR1_YEAST SWR1_YEAST]] Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.<ref>PMID:14690608</ref> <ref>PMID:15045029</ref> <ref>PMID:15353583</ref> <ref>PMID:14645854</ref> | |||
==About this Structure== | |||
[[4m6b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6B OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024507717</ref><references group="xtra"/><references/> | |||
[[Category: DNA helicase]] | |||
[[Category: Bai, Y W.]] | |||
[[Category: Chen, J H.]] | |||
[[Category: Feng, H Q.]] | |||
[[Category: Girlando, R.]] | |||
[[Category: Hong, J J.]] | |||
[[Category: Jiang, J S.]] | |||
[[Category: Ranjan, A.]] | |||
[[Category: Wang, F.]] | |||
[[Category: Wu, C.]] | |||
[[Category: Xiao, T S.]] | |||
[[Category: Chromatin remodeler]] | |||
[[Category: Histone binding]] | |||
[[Category: Structural protein-hydrolase complex]] | |||