4j5a: Difference between revisions
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{{STRUCTURE_4j5a| PDB=4j5a | SCENE= }} | |||
===Human Cyclophilin D Complexed with an Inhibitor=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref> | |||
==About this Structure== | |||
[[4j5a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5A OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Peptidylprolyl isomerase]] | |||
[[Category: Bessin, Y.]] | |||
[[Category: Colliandre, L.]] | |||
[[Category: Gelin, M.]] | |||
[[Category: Guichou, J F.]] | |||
[[Category: Isomerase-isomerase inhibitor complex]] | |||
