4kmc: Difference between revisions
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{{STRUCTURE_4kmc| PDB=4kmc | SCENE= }} | |||
===Structure analysis of M. Tuberculosis rRNA transcriptional regulator CarD and its interaction with T. Aquaticus RNA polymerase-BETA1 domain=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CARD_MYCTU CARD_MYCTU]] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.<ref>PMID:19596241</ref> <ref>PMID:22904282</ref> | |||
==About this Structure== | |||
[[4kmc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KMC OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Gangwar, S P.]] | |||
[[Category: Meena, S R.]] | |||
[[Category: Saxena, A K.]] | |||
[[Category: Rna polymerase beta1 domain]] | |||
[[Category: Rrna transcriptional regulator]] | |||
[[Category: Transcription]] | |||
[[Category: Unknown fold]] | |||
Revision as of 17:48, 19 February 2014
Structure analysis of M. Tuberculosis rRNA transcriptional regulator CarD and its interaction with T. Aquaticus RNA polymerase-BETA1 domain
Function
[CARD_MYCTU] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.[1] [2]
About this Structure
4kmc is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041. PMID:19596241 doi:10.1016/j.cell.2009.04.041
- ↑ Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol. 2012 Oct;194(20):5621-31. Epub 2012 Aug 17. PMID:22904282 doi:10.1128/JB.00879-12
