2wty: Difference between revisions
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{{STRUCTURE_2wty| PDB=2wty | SCENE= }} | {{STRUCTURE_2wty| PDB=2wty | SCENE= }} | ||
===Crystal structure of the homodimeric MafB in complex with the T-MARE binding site=== | |||
{{ABSTRACT_PUBMED_24530283}} | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/MAFB_MOUSE MAFB_MOUSE]] Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.<ref>PMID:10790365</ref> <ref>PMID:16443760</ref> <ref>PMID:16847325</ref> <ref>PMID:17901057</ref> <ref>PMID:17548468</ref> <ref>PMID:18199433</ref> <ref>PMID:19143053</ref> | |||
==About this Structure== | |||
[[2wty]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WTY OCA]. | |||
== | ==Reference== | ||
<ref group="xtra">PMID:024530283</ref><references group="xtra"/><references/> | |||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Holton, S.]] | [[Category: Holton, S.]] | ||
[[Category: Textor, L Consani.]] | [[Category: Textor, L Consani.]] | ||
