3hw2: Difference between revisions
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{{STRUCTURE_3hw2| PDB=3hw2 | SCENE= }} | {{STRUCTURE_3hw2| PDB=3hw2 | SCENE= }} | ||
===Crystal structure of the SifA-SKIP(PH) complex=== | ===Crystal structure of the SifA-SKIP(PH) complex=== | ||
{{ABSTRACT_PUBMED_19801640}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> [[http://www.uniprot.org/uniprot/PKHM2_HUMAN PKHM2_HUMAN]] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.<ref>PMID:15905402</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3hw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3hw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HW2 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019801640</ref><references group="xtra"/> | <ref group="xtra">PMID:019801640</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: | [[Category: Salty]] | ||
[[Category: Bignon, C.]] | [[Category: Bignon, C.]] | ||
[[Category: Bourne, Y.]] | [[Category: Bourne, Y.]] | ||
