3kcy: Difference between revisions

Line 1:

~~[[Image:3kcy.png|left|200px]]~~

===Factor inhibiting HIF-1 alpha in complex with 8-hydroxyquinoline===

~~{{ABSTRACT_PUBMED_20396966}}~~

==Function==

[[http://www.uniprot.org/uniprot/HIF1N_HUMAN HIF1N_HUMAN]] Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<ref>PMID:12080085</ref> <ref>PMID:12042299</ref> <ref>PMID:17003112</ref> <ref>PMID:18299578</ref> <ref>PMID:19245366</ref> <ref>PMID:17573339</ref> <ref>PMID:21251231</ref> <ref>PMID:21177872</ref>

==About this Structure==

[[3kcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCY OCA].

[[3kcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCY OCA].

==See Also==

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==Reference==

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Peptide-aspartate beta-dioxygenase]]

[[Category: Choe, J.]]

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@@ Line 1: / Line 1: @@
-[[Image:3kcy.png|left|200px]]
 {{STRUCTURE_3kcy|  PDB=3kcy  |  SCENE=  }}
 ===Factor inhibiting HIF-1 alpha in complex with 8-hydroxyquinoline===
+{{ABSTRACT_PUBMED_20396966}}
-{{ABSTRACT_PUBMED_20396966}}
+==Function==
+[[http://www.uniprot.org/uniprot/HIF1N_HUMAN HIF1N_HUMAN]] Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.<ref>PMID:12080085</ref> <ref>PMID:12042299</ref> <ref>PMID:17003112</ref> <ref>PMID:18299578</ref> <ref>PMID:19245366</ref> <ref>PMID:17573339</ref> <ref>PMID:21251231</ref> <ref>PMID:21177872</ref>
 ==About this Structure==
-[[3kcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCY OCA].
+[[3kcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCY OCA].
 ==See Also==
@@ Line 14: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:020396966</ref><references group="xtra"/>
+<ref group="xtra">PMID:020396966</ref><references group="xtra"/><references/>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Peptide-aspartate beta-dioxygenase]]
 [[Category: Choe, J.]]