4llp: Difference between revisions
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{{STRUCTURE_4llp| PDB=4llp | SCENE= }} | |||
===Crystal structure of PDE10A2 with fragment ZT401=== | |||
{{ABSTRACT_PUBMED_24375910}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==About this Structure== | |||
[[4llp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLP OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024375910</ref><references group="xtra"/><references/> | |||
[[Category: Badger, J.]] | |||
[[Category: Chie-Leon, B.]] | |||
[[Category: Logan, C.]] | |||
[[Category: Nienaber, V.]] | |||
[[Category: Sridhar, V.]] | |||
[[Category: Fragment screening]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 17:54, 3 March 2014
Crystal structure of PDE10A2 with fragment ZT401
Template:ABSTRACT PUBMED 24375910
Function
[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]
About this Structure
4llp is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE. Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. J Biomol Screen. 2013 Dec 27. PMID:24375910 doi:https://dx.doi.org/10.1177/1087057113516493
