4ogj: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ogj|  PDB=4ogj  |  SCENE=  }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348===


The entry 4ogj is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 


Authors: Filippakopoulos, P., Picaud, S., Jose, B., Martin, S., Fedorov, O., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
==Function==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Description: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348
==About this Structure==
[[4ogj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGJ OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Delft, F Von.]]
[[Category: Edwards, A M.]]
[[Category: Fedorov, O.]]
[[Category: Filippakopoulos, P.]]
[[Category: Jose, B.]]
[[Category: Knapp, S.]]
[[Category: Martin, S.]]
[[Category: Picaud, S.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Bromodomain]]
[[Category: Bromodomain containing protein 4]]
[[Category: Flt3 kinase inhibitor]]
[[Category: Jak2 kinase inhibitor]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transcription-inhibitor complex]]

Revision as of 18:28, 3 March 2014

Template:STRUCTURE 4ogj

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4ogj is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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