4oca: Difference between revisions
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{{STRUCTURE_4oca| PDB=4oca | SCENE= }} | |||
===Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N=== | |||
{{ABSTRACT_PUBMED_24460375}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/F5ZUF5_SALTU F5ZUF5_SALTU]] Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).[HAMAP-Rule:MF_01167][SAAS:SAAS022850_004_033570] | |||
==About this Structure== | |||
[[4oca]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCA OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024460375</ref><references group="xtra"/><references/> | |||
[[Category: UDP-4-amino-4-deoxy-L-arabinose aminotransferase]] | |||
[[Category: Lee, M.]] | |||
[[Category: Sousa, M C.]] | |||
[[Category: Aminotransferase]] | |||
[[Category: Transferase]] | |||
Revision as of 13:30, 12 March 2014
Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N
Template:ABSTRACT PUBMED 24460375
Function
[F5ZUF5_SALTU] Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).[HAMAP-Rule:MF_01167][SAAS:SAAS022850_004_033570]
About this Structure
4oca is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Lee M, Sousa MC. Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria. Biochemistry. 2014 Feb 4;53(4):796-805. doi: 10.1021/bi4015677. Epub 2014 Jan 24. PMID:24460375 doi:https://dx.doi.org/10.1021/bi4015677
