4oq6: Difference between revisions
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' | {{STRUCTURE_4oq6| PDB=4oq6 | SCENE= }} | ||
===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid=== | |||
{{ABSTRACT_PUBMED_24582986}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
==About this Structure== | |||
[[4oq6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024582986</ref><references group="xtra"/><references/> | |||
[[Category: Kunzer, A R.]] | |||
[[Category: Park, C.]] | |||
[[Category: Petros, A M.]] | |||
[[Category: Song, D.]] | |||
[[Category: Souers, A J.]] | |||
[[Category: Sun, C.]] | |||
[[Category: Swann, S L.]] | |||
[[Category: Swinger, K.]] | |||
[[Category: Wendt, M D.]] | |||
[[Category: Zhang, H.]] | |||
[[Category: Apoptosis-inhibitor complex]] | |||