3wj9: Difference between revisions
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{{STRUCTURE_3wj9| PDB=3wj9 | SCENE= }} | |||
===Crystal structure of the eukaryotic initiation factor=== | |||
{{ABSTRACT_PUBMED_24569939}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/EIF2A_SCHPO EIF2A_SCHPO]] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins (By similarity). | |||
==About this Structure== | |||
[[3wj9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WJ9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024569939</ref><references group="xtra"/><references/> | |||
[[Category: Ito, T.]] | |||
[[Category: Kashiwagi, K.]] | |||
[[Category: Yokoyama, S.]] | |||
[[Category: Beta-propeller]] | |||
[[Category: Translation]] | |||
Revision as of 13:35, 12 March 2014
Crystal structure of the eukaryotic initiation factor
Template:ABSTRACT PUBMED 24569939
Function
[EIF2A_SCHPO] Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins (By similarity).
About this Structure
3wj9 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Kashiwagi K, Ito T, Yokoyama S. Crystal structure of the eukaryotic translation initiation factor 2A from Schizosaccharomyces pombe. J Struct Funct Genomics. 2014 Feb 26. PMID:24569939 doi:https://dx.doi.org/10.1007/s10969-014-9177-y
