4eqk: Difference between revisions
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{{STRUCTURE_4eqk| PDB=4eqk | SCENE= }} | {{STRUCTURE_4eqk| PDB=4eqk | SCENE= }} | ||
===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP=== | ===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP=== | ||
{{ABSTRACT_PUBMED_23436652}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PB2_I68A4 PB2_I68A4]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[4eqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4eqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I68a4 I68a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQK OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023436652</ref><references group="xtra"/><references/> | |||
[[Category: I68a4]] | |||
[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
[[Category: Meng, G.]] | [[Category: Meng, G.]] | ||
Revision as of 13:42, 12 March 2014
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP
Template:ABSTRACT PUBMED 23436652
Function
[PB2_I68A4] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
About this Structure
4eqk is a 1 chain structure with sequence from I68a4. Full crystallographic information is available from OCA.
Reference
- Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub, 2013 Feb 22. PMID:23436652 doi:10.1074/jbc.M112.392878
