4nat: Difference between revisions
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{{STRUCTURE_4nat| PDB=4nat | SCENE= }} | |||
===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase=== | |||
{{ABSTRACT_PUBMED_24041904}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). | |||
==About this Structure== | |||
[[4nat]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024041904</ref><references group="xtra"/><references/> | |||
[[Category: Pantetheine-phosphate adenylyltransferase]] | |||
[[Category: Lahiri, S D.]] | |||
[[Category: Coabc]] | |||
[[Category: Coad]] | |||
[[Category: Cytosolic]] | |||
[[Category: Panthetheine]] | |||
[[Category: Phosphopanthetheine adenylyltransferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 13:44, 12 March 2014
Inhibitors of 4-Phosphopanthetheine Adenylyltransferase
Template:ABSTRACT PUBMED 24041904
Function
[COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
About this Structure
4nat is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. , Epub 2013 Sep 16. PMID:24041904 doi:https://dx.doi.org/10.1128/AAC.01661-13
