4n0d: Difference between revisions
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{{STRUCTURE_4n0d| PDB=4n0d | SCENE= }} | |||
===Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | |||
==About this Structure== | |||
[[4n0d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0D OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Heterotrimeric G-protein GTPase]] | |||
[[Category: Hamm, H E.]] | |||
[[Category: Iverson, T M.]] | |||
[[Category: Preininger, A M.]] | |||
[[Category: Sarwar, M.]] | |||
[[Category: Thaker, T M.]] | |||
[[Category: Gdp]] | |||
[[Category: Gtp]] | |||
[[Category: Guanine nucleotide binding protein]] | |||
[[Category: Hydrolase]] | |||
[[Category: Magnesium binding]] | |||
[[Category: Rossman fold]] | |||
Revision as of 14:01, 12 March 2014
Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS
Function
[GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.[1]
About this Structure
4n0d is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Shu FJ, Ramineni S, Amyot W, Hepler JR. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25. PMID:16870394 doi:https://dx.doi.org/10.1016/j.cellsig.2006.06.002
