3unm: Difference between revisions

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~~[[Image:3unm.png|left|200px]]~~

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===Crystal Structure of The Human MDC1 FHA Domain===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_22234877}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 22234877 is~~ the ~~PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_22234877}}~~

==About this Structure==

[[3unm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UNM OCA].

[[3unm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UNM OCA].

==Reference==

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Luo, S.]]

[[Category: Ye, K.]]

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@@ Line 1: / Line 1: @@
-[[Image:3unm.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3unm", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3unm|  PDB=3unm  |  SCENE=  }}
 ===Crystal Structure of The Human MDC1 FHA Domain===
+{{ABSTRACT_PUBMED_22234877}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_22234877}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 22234877 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22234877}}
 ==About this Structure==
-[[3unm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UNM OCA].
+[[3unm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UNM OCA].
 ==Reference==
-<ref group="xtra">PMID:022234877</ref><references group="xtra"/>
+<ref group="xtra">PMID:022234877</ref><references group="xtra"/><references/>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Luo, S.]]
 [[Category: Ye, K.]]