4ps4: Difference between revisions
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{{STRUCTURE_4ps4| PDB=4ps4 | SCENE= }} | |||
===Crystal structure of the complex between IL-13 and M1295 FAB=== | |||
{{ABSTRACT_PUBMED_20226193}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. | |||
==About this Structure== | |||
[[4ps4]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l5y 3l5y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PS4 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:020226193</ref><references group="xtra"/><references/> | |||
[[Category: Gilliland, G L.]] | |||
[[Category: Malia, T.]] | |||
[[Category: Obmolova, G.]] | |||
[[Category: Teplyakov, A.]] | |||
[[Category: Alpha-helical bundle]] | |||
[[Category: Cytokine]] | |||
[[Category: Disulfide bond]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Immune system]] | |||
[[Category: Immunoglobulin fold]] | |||
[[Category: Monoclonal antibody]] | |||
[[Category: Secreted]] | |||
Revision as of 08:40, 19 March 2014
Crystal structure of the complex between IL-13 and M1295 FAB
Template:ABSTRACT PUBMED 20226193
Disease
[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
Function
[IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
About this Structure
4ps4 is a 3 chain structure. This structure supersedes the now removed PDB entry 3l5y. Full crystallographic information is available from OCA.
Reference
- Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC. Human framework adaptation of a mouse anti-human IL-13 antibody. J Mol Biol. 2010 Apr 30;398(2):214-31. Epub 2010 Mar 10. PMID:20226193 doi:10.1016/j.jmb.2010.03.004
