2mjv: Difference between revisions
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{{STRUCTURE_2mjv| PDB=2mjv | SCENE= }} | |||
===Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide=== | |||
{{ABSTRACT_PUBMED_24525235}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TWST1_HUMAN TWST1_HUMAN]] Isolated scaphocephaly;Isolated brachycephaly;Saethre-Chotzen syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TWST1_HUMAN TWST1_HUMAN]] Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.<ref>PMID:12553906</ref> [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[2mjv]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJV OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024525235</ref><references group="xtra"/><references/> | |||
[[Category: Zeng, L.]] | |||
[[Category: Zhou, M.]] | |||
[[Category: Transcription]] | |||
[[Category: Tumorigenesis]] | |||
