4cp3: Difference between revisions
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{{STRUCTURE_4cp3| PDB=4cp3 | SCENE= }} | |||
===The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.=== | |||
{{ABSTRACT_PUBMED_24595451}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | |||
==About this Structure== | |||
[[4cp3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CP3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024595451</ref><references group="xtra"/><references/> | |||
[[Category: Evans, S E.]] | |||
[[Category: Fairall, L.]] | |||
[[Category: Ferrigno, P K.]] | |||
[[Category: Ford, R.]] | |||
[[Category: Goult, B T.]] | |||
[[Category: Jamieson, A G.]] | |||
[[Category: Schwabe, J W.R.]] | |||
[[Category: Wagner, S D.]] | |||
[[Category: Antibiotic]] | |||
[[Category: Btb/poz]] | |||
[[Category: Immune system]] | |||
[[Category: Inhibitor]] | |||
[[Category: Rifamycin]] | |||
[[Category: Smrt]] | |||
[[Category: Transcriptional repressor]] | |||
Revision as of 08:45, 19 March 2014
The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.
Template:ABSTRACT PUBMED 24595451
Disease
[BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
Function
[BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.[1] [2]
About this Structure
4cp3 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD. The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain. PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection , 2014. PMID:24595451 doi:https://dx.doi.org/10.1371/journal.pone.0090889
- ↑ Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998 Jul 1;12(13):1953-61. PMID:9649500
- ↑ Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243 doi:10.1016/j.molcel.2007.12.026
