4miw: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase===

The ~~entry 4miw~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/Q6GWS2_9VIRU Q6GWS2_9VIRU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

~~Authors~~: ~~Wallat, G.D., Huang, Q., Wang, W., Dong, H~~.~~, Ly, H~~.~~, Liang, Y~~.~~, Dong, C~~.

==About this Structure==

[[4miw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIW OCA].

~~Description~~: ~~High-resolution structure of the N~~-~~terminal endonuclease domain of the Lassa virus L~~ polymerase

==Reference==

[[Category: RNA-directed RNA polymerase]]

[[Category: Dong, C.]]

[[Category: Dong, H.]]

[[Category: Huang, Q.]]

[[Category: Liang, Y.]]

[[Category: Ly, H.]]

[[Category: Wallat, G D.]]

[[Category: Wang, W.]]

[[Category: Beta sheet]]

[[Category: Endonuclease]]

[[Category: Endoribonuclease type ii]]

[[Category: Helix]]

[[Category: Transferase]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4miw|  PDB=4miw  |  SCENE=  }}
+===High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase===
+{{ABSTRACT_PUBMED_24516554}}
-The entry 4miw is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/Q6GWS2_9VIRU Q6GWS2_9VIRU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
-Authors: Wallat, G.D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
+==About this Structure==
+[[4miw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIW OCA].
-Description: High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase
+==Reference==
+<ref group="xtra">PMID:024516554</ref><references group="xtra"/><references/>
+[[Category: RNA-directed RNA polymerase]]
+[[Category: Dong, C.]]
+[[Category: Dong, H.]]
+[[Category: Huang, Q.]]
+[[Category: Liang, Y.]]
+[[Category: Ly, H.]]
+[[Category: Wallat, G D.]]
+[[Category: Wang, W.]]
+[[Category: Beta sheet]]
+[[Category: Endonuclease]]
+[[Category: Endoribonuclease type ii]]
+[[Category: Helix]]
+[[Category: Transferase]]
+[[Category: Viral protein]]