4ibi: Difference between revisions

Line 1:

~~WITHDRAWN~~: The ~~PDB entry~~ 4IBI ~~was withdrawn~~.

===Ebola virus VP35 bound to small molecule===

==Function==

[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>

==About this Structure==

[[4ibi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBI OCA].

==Reference==

[[Category: Amarasinghe, G K.]]

[[Category: Binning, J M.]]

[[Category: Borek, D M.]]

[[Category: Brown, C S.]]

[[Category: Leung, D W.]]

[[Category: Otwinowski, Z.]]

[[Category: Peterson, D S.]]

[[Category: Ramanan, P.]]

[[Category: Stubbs, A J.]]

[[Category: Xu, W.]]

[[Category: Interferon inhibitor domain]]

[[Category: Transcription-transcription inhibitor complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-WITHDRAWN: The PDB entry 4IBI was withdrawn.
+{{STRUCTURE_4ibi|  PDB=4ibi  |  SCENE=  }}
+===Ebola virus VP35 bound to small molecule===
+{{ABSTRACT_PUBMED_24495995}}
+==Function==
+[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
+==About this Structure==
+[[4ibi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBI OCA].
+==Reference==
+<ref group="xtra">PMID:024495995</ref><references group="xtra"/><references/>
+[[Category: Amarasinghe, G K.]]
+[[Category: Binning, J M.]]
+[[Category: Borek, D M.]]
+[[Category: Brown, C S.]]
+[[Category: Leung, D W.]]
+[[Category: Otwinowski, Z.]]
+[[Category: Peterson, D S.]]
+[[Category: Ramanan, P.]]
+[[Category: Stubbs, A J.]]
+[[Category: Xu, W.]]
+[[Category: Interferon inhibitor domain]]
+[[Category: Transcription-transcription inhibitor complex]]