4icc: Difference between revisions
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{{STRUCTURE_4icc| PDB=4icc | SCENE= }} | {{STRUCTURE_4icc| PDB=4icc | SCENE= }} | ||
===Crystal structure of human AKR1B10 complexed with NADP+ and JF0064=== | ===Crystal structure of human AKR1B10 complexed with NADP+ and JF0064=== | ||
{{ABSTRACT_PUBMED_24598757}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024598757</ref><references group="xtra"/><references/> | ||
[[Category: Cousido-Siah, A.]] | [[Category: Cousido-Siah, A.]] | ||
[[Category: Farres, J.]] | [[Category: Farres, J.]] | ||
Revision as of 09:03, 19 March 2014
Crystal structure of human AKR1B10 complexed with NADP+ and JF0064
Template:ABSTRACT PUBMED 24598757
Function
[AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.[1]
About this Structure
4icc is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Cousido-Siah A, Ruiz FX, Mitschler A, Porte S, de Lera AR, Martin MJ, Manzanaro S, de la Fuente JA, Terwesten F, Betz M, Klebe G, Farres J, Pares X, Podjarny A. Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):889-903. doi:, 10.1107/S1399004713033452. Epub 2014 Feb 27. PMID:24598757 doi:https://dx.doi.org/10.1107/S1399004713033452
