4lnw: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4lnw|  PDB=4lnw  |  SCENE=  }}
===Crystal structure of TR-alpha bound to T3 in a second site===
{{ABSTRACT_PUBMED_24552590}}


The entry 4lnw is ON HOLD until Paper Publication
==Disease==
[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[http://omim.org/entry/614450 614450]]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>  


Authors: Puhl, A.C., Aparicio, R., Polikarpov, I.
==Function==
[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Nuclear hormone receptor. High affinity receptor for triiodothyronine.  


Description: Crystal structure of TR-alpha bound to T3 in a second site
==About this Structure==
[[4lnw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNW OCA].
 
==Reference==
<ref group="xtra">PMID:024552590</ref><references group="xtra"/><references/>
[[Category: Aparicio, R.]]
[[Category: Polikarpov, I.]]
[[Category: Puhl, A C.]]
[[Category: Mainly alpha orthogonal bundle]]
[[Category: Transcription]]
[[Category: Transcription factor]]
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