4nf9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of the Knl1/Nsl1 complex===

The entry ~~4nf9 is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Autosomal recessive primary microcephaly. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1. May give rise to a KMT2A/MLL1-CASC5 fusion protein. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Petrovic, A~~.~~, Mosalaganti, S~~.~~, Keller, J~~.~~, Mattiuzzo, M~~., ~~Overlack, K~~.~~, Wohlgemuth, S~~.~~, Pasqualato, S~~.~~, Raunser, S~~.~~, Musacchio, A~~.

==Function==

[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.<ref>PMID:15502821</ref> <ref>PMID:17981135</ref> <ref>PMID:18045986</ref> [[http://www.uniprot.org/uniprot/NSL1_HUMAN NSL1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:16585270</ref>

~~Description~~: ~~Structure of the Knl1~~/~~Nsl1 complex~~

==About this Structure==

[[4nf9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NF9 OCA].

==Reference==

[[Category: Keller, J.]]

[[Category: Mattiuzzo, M.]]

[[Category: Mosalaganti, S.]]

[[Category: Musacchio, A.]]

[[Category: Overlack, K.]]

[[Category: Pasqualato, S.]]

[[Category: Petrovic, A.]]

[[Category: Raunser, S.]]

[[Category: Wohlgemuth, S.]]

[[Category: Cell cycle]]

[[Category: Rwd domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nf9|  PDB=4nf9  |  SCENE=  }}
+===Structure of the Knl1/Nsl1 complex===
+{{ABSTRACT_PUBMED_24530301}}
-The entry 4nf9 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Autosomal recessive primary microcephaly. A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1. May give rise to a KMT2A/MLL1-CASC5 fusion protein.  The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Petrovic, A., Mosalaganti, S., Keller, J., Mattiuzzo, M., Overlack, K., Wohlgemuth, S., Pasqualato, S., Raunser, S., Musacchio, A.
+==Function==
+[[http://www.uniprot.org/uniprot/CASC5_HUMAN CASC5_HUMAN]] Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.<ref>PMID:15502821</ref> <ref>PMID:17981135</ref> <ref>PMID:18045986</ref>  [[http://www.uniprot.org/uniprot/NSL1_HUMAN NSL1_HUMAN]] Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<ref>PMID:16585270</ref>
-Description: Structure of the Knl1/Nsl1 complex
+==About this Structure==
+[[4nf9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NF9 OCA].
+==Reference==
+<ref group="xtra">PMID:024530301</ref><references group="xtra"/><references/>
+[[Category: Keller, J.]]
+[[Category: Mattiuzzo, M.]]
+[[Category: Mosalaganti, S.]]
+[[Category: Musacchio, A.]]
+[[Category: Overlack, K.]]
+[[Category: Pasqualato, S.]]
+[[Category: Petrovic, A.]]
+[[Category: Raunser, S.]]
+[[Category: Wohlgemuth, S.]]
+[[Category: Cell cycle]]
+[[Category: Rwd domain]]