4h5w: Difference between revisions
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{{STRUCTURE_4h5w| PDB=4h5w | SCENE= }} | |||
===HSC70 NBD with betaine=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> | |||
==About this Structure== | |||
[[4h5w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5W OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Stec, B.]] | |||
[[Category: Hsc70 nbd]] | |||
[[Category: Transcription]] | |||
Revision as of 09:29, 19 March 2014
HSC70 NBD with betaine
Function
[HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.[1]
About this Structure
4h5w is a 2 chain structure. Full crystallographic information is available from OCA.
