4o7x: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4o7x|  PDB=4o7x  |  SCENE=  }}
===Crystal structure of human ALKBH5 in complex with Mn2+===


The entry 4o7x is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>  


Authors: Feng, C., Chen, Z., Liu, Y.
==About this Structure==
[[4o7x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7X OCA].  


Description: Crystal structure of human ALKBH5 in complex with Mn2+
==Reference==
<references group="xtra"/><references/>
[[Category: Chen, Z.]]
[[Category: Feng, C.]]
[[Category: Liu, Y.]]
[[Category: 6-methyl adenosine]]
[[Category: Demethylation]]
[[Category: Human dioxygenase]]
[[Category: Metal-binding]]
[[Category: Nucleus]]
[[Category: Oxidoreductase]]
[[Category: Protein/dna interaction]]
[[Category: Rna repair]]