4o7x: Difference between revisions
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{{STRUCTURE_4o7x| PDB=4o7x | SCENE= }} | |||
===Crystal structure of human ALKBH5 in complex with Mn2+=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref> | |||
==About this Structure== | |||
[[4o7x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7X OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Chen, Z.]] | |||
[[Category: Feng, C.]] | |||
[[Category: Liu, Y.]] | |||
[[Category: 6-methyl adenosine]] | |||
[[Category: Demethylation]] | |||
[[Category: Human dioxygenase]] | |||
[[Category: Metal-binding]] | |||
[[Category: Nucleus]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Protein/dna interaction]] | |||
[[Category: Rna repair]] | |||